Your browser doesn't support javascript.
loading
Clue of Diagnosis for Autoimmune Gastritis.
Nishizawa, Toshihiro; Yoshida, Shuntaro; Watanabe, Hidenobu; Toyoshima, Akira; Kataoka, Yosuke; Takahashi, Yoshiyuki; Kanazawa, Takamitsu; Ebinuma, Hirotoshi; Suzuki, Hidekazu; Koike, Kazuhiko; Toyoshima, Osamu.
Afiliação
  • Nishizawa T; Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
  • Yoshida S; Department of Gastroenterology and Hepatology, International University of Health and Welfare Narita Hospital, Chiba, Japan.
  • Watanabe H; Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
  • Toyoshima A; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Kataoka Y; Pathology and Cytology Laboratory Japan, Tokyo, Japan.
  • Takahashi Y; Department of Colorectal Surgery, Japanese Red Cross Medical Center, Tokyo, Japan.
  • Kanazawa T; Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
  • Ebinuma H; Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Suzuki H; Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
  • Koike K; Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan.
  • Toyoshima O; Department of Gastrointestinal Surgery, JR Tokyo General Hospital, Tokyo, Japan.
Digestion ; 102(6): 903-910, 2021.
Article em En | MEDLINE | ID: mdl-34198294
ABSTRACT

BACKGROUND:

The diagnostic clues for autoimmune gastritis (AIG) can be classified into 2 categories endoscopic findings and pathological diagnosis. We believe that research on the AIG detection rate by endoscopists could provide a better understanding of the diagnosis of AIG. This study aimed to clarify the ratio of the endoscopic and the pathological diagnoses of AIG.

METHODS:

We retrospectively reviewed consecutive patients who underwent esophagogastroduodenoscopy (EGD). During their first EGD, the gastric mucosa with C2 atrophy or more was biopsied for pathological evaluation based on the updated Sydney system. A gastric biopsy was also performed after Helicobacter pylori eradication, obtaining specimens from at least 2 sites, the greater curvature of the corpus and the antrum. We enrolled patients who were positive for the anti-parietal cell antibody and were diagnosed with AIG, histologically and/or endoscopically. The detection rates of AIG were compared between endoscopic diagnosis and pathological diagnosis.

RESULTS:

A total of 10,822 patients underwent EGD during the study period. Finally, 41 patients with AIG were enrolled, leading to an AIG prevalence of 0.38% in this study. As for the clue leading to AIG detection, 31.7% (13/41) were diagnosed through endoscopy (proximal-predominant atrophy), and 68.3% (28/41) were diagnosed pathologically. The AIG detection rate by endoscopists in the posteradication group was significantly lower than in the H. pylori-negative group (p < 0.05).

CONCLUSION:

Endoscopists frequently overlooked AIG, especially in posteradication cases. Pathological assessment using the updated Sydney system after H. pylori eradication might be a promising strategy to detect AIG better.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Helicobacter pylori / Infecções por Helicobacter / Gastrite Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Digestion Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Helicobacter pylori / Infecções por Helicobacter / Gastrite Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Digestion Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão