LAMC1 upregulation via TGFß induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-&#954;B-CXCL1-STAT3.

Fang, Lingling; Che, Yun; Zhang, Chaoqi; Huang, Jianbing; Lei, Yuanyuan; Lu, Zhiliang; Sun, Nan; He, Jie

LAMC1 upregulation via TGFß induces inflammatory cancer-associated fibroblasts in esophageal squamous cell carcinoma via NF-κB-CXCL1-STAT3.

Fang, Lingling; Che, Yun; Zhang, Chaoqi; Huang, Jianbing; Lei, Yuanyuan; Lu, Zhiliang; Sun, Nan; He, Jie.

Afiliação

Fang L; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Che Y; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhang C; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Huang J; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lei Y; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Lu Z; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Sun N; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
He J; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Mol Oncol ; 15(11): 3125-3146, 2021 11.

Article em En | MEDLINE | ID: mdl-34218518

Assuntos

Fibroblastos Associados a Câncer; Carcinoma de Células Escamosas; Neoplasias Esofágicas; Carcinoma de Células Escamosas do Esôfago; Fibroblastos Associados a Câncer/metabolismo; Carcinoma de Células Escamosas/patologia; Linhagem Celular Tumoral; Movimento Celular/genética; Proliferação de Células/genética; Quimiocina CXCL1/genética; Quimiocina CXCL1/metabolismo; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas do Esôfago/genética; Carcinoma de Células Escamosas do Esôfago/metabolismo; Regulação Neoplásica da Expressão Gênica; Humanos; Laminina; NF-kappa B/metabolismo; Fator de Transcrição STAT3; Fator de Crescimento Transformador beta/metabolismo; Microambiente Tumoral; Regulação para Cima/genética

Palavras-chave

CAF; CXCL1; ESCC; LAMC1; heterogeneity; transforming growth factor ß

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Fibroblastos Associados a Câncer / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Mol Oncol Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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