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Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study.
Hartung, Hans-Peter; Derfuss, Tobias; Cree, Bruce Ac; Sormani, Maria Pia; Selmaj, Krzysztof; Stutters, Jonathan; Prados, Ferran; MacManus, David; Schneble, Hans-Martin; Lambert, Estelle; Porchet, Hervé; Glanzman, Robert; Warne, David; Curtin, Francois; Kornmann, Gabrielle; Buffet, Bénédicte; Kremer, David; Küry, Patrick; Leppert, David; Rückle, Thomas; Barkhof, Frederik.
Afiliação
  • Hartung HP; Department of Neurology, Universitätsklinikum Düsseldorf (UKD) and Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany/Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany/Brain and Mind Centre, The Univ
  • Derfuss T; Department of Neurology, Universitätsspital Basel, Basel, Switzerland.
  • Cree BA; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
  • Sormani MP; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy/Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ospedale Policlinico San Martino, Genova, Italy.
  • Selmaj K; Department of Neurology, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland/Department of Neurology, Medical Academy of Lódz, Lódz, Poland.
  • Stutters J; Nuclear Magnetic Resonance (NMR) Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Prados F; Nuclear Magnetic Resonance (NMR) Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK/Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering,
  • MacManus D; Nuclear Magnetic Resonance (NMR) Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Schneble HM; Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
  • Lambert E; Institut de Recherches Internationales Servier, Suresnes, France.
  • Porchet H; GeNeuro SA, Geneva, Switzerland/Department of Pharmacology, University of Pretoria, Pretoria, South Africa.
  • Glanzman R; GeNeuro SA, Geneva, Switzerland.
  • Warne D; GeNeuro SA, Geneva, Switzerland.
  • Curtin F; GeNeuro SA, Geneva, Switzerland; Clinical Pharmacology and Toxicology Division, Geneva University Hospitals, Geneva, Switzerland.
  • Kornmann G; GeNeuro SA, Geneva, Switzerland.
  • Buffet B; GeNeuro SA, Geneva, Switzerland.
  • Kremer D; Department of Neurology, Universitätsklinikum Düsseldorf (UKD) and Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany/Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
  • Küry P; Department of Neurology, Universitätsklinikum Düsseldorf (UKD) and Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany/Center for Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
  • Leppert D; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia/GeNeuro SA, Geneva, Switzerland.
  • Rückle T; GeNeuro SA, Geneva, Switzerland.
  • Barkhof F; Nuclear Magnetic Resonance (NMR) Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK/Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering,
Mult Scler ; 28(3): 429-440, 2022 Mar.
Article em En | MEDLINE | ID: mdl-34240656
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Recidivante-Remitente / Anticorpos Monoclonais Humanizados / Esclerose Múltipla Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Mult Scler Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esclerose Múltipla Recidivante-Remitente / Anticorpos Monoclonais Humanizados / Esclerose Múltipla Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Revista: Mult Scler Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article