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GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
Liang, Jun; Zbieg, Jason R; Blake, Robert A; Chang, Jae H; Daly, Stephen; DiPasquale, Antonio G; Friedman, Lori S; Gelzleichter, Thomas; Gill, Matthew; Giltnane, Jennifer M; Goodacre, Simon; Guan, Jane; Hartman, Steven J; Ingalla, Ellen Rei; Kategaya, Lorn; Kiefer, James R; Kleinheinz, Tracy; Labadie, Sharada S; Lai, Tommy; Li, Jun; Liao, Jiangpeng; Liu, Zhiguo; Mody, Vidhi; McLean, Neville; Metcalfe, Ciara; Nannini, Michelle A; Oeh, Jason; O'Rourke, Martin G; Ortwine, Daniel F; Ran, Yingqing; Ray, Nicholas C; Roussel, Fabien; Sambrone, Amy; Sampath, Deepak; Schutt, Leah K; Vinogradova, Maia; Wai, John; Wang, Tao; Wertz, Ingrid E; White, Jonathan R; Yeap, Siew Kuen; Young, Amy; Zhang, Birong; Zheng, Xiaoping; Zhou, Wei; Zhong, Yu; Wang, Xiaojing.
Afiliação
  • Liang J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Zbieg JR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Blake RA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Chang JH; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Daly S; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • DiPasquale AG; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Friedman LS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Gelzleichter T; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Gill M; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Giltnane JM; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Goodacre S; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Guan J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Hartman SJ; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Ingalla ER; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Kategaya L; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Kiefer JR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Kleinheinz T; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Labadie SS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Lai T; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China.
  • Li J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Liao J; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China.
  • Liu Z; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China.
  • Mody V; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • McLean N; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Metcalfe C; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Nannini MA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Oeh J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • O'Rourke MG; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Ortwine DF; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Ran Y; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Ray NC; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Roussel F; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Sambrone A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sampath D; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Schutt LK; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Vinogradova M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wai J; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China.
  • Wang T; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China.
  • Wertz IE; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • White JR; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Yeap SK; Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom.
  • Young A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhang B; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Zheng X; WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China.
  • Zhou W; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhong Y; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wang X; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
J Med Chem ; 64(16): 11841-11856, 2021 08 26.
Article em En | MEDLINE | ID: mdl-34251202
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carbolinas / Receptor alfa de Estrogênio / Antagonistas do Receptor de Estrogênio / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carbolinas / Receptor alfa de Estrogênio / Antagonistas do Receptor de Estrogênio / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos