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Patients perspectives on drug shortages in six European hospital settings - a cross sectional study.
Kuruc Poje, Darija; Kifer, Domagoj; Huys, Isabelle; Miranda, Joao; Jenzer, Helena; Miljkovic, Nenad; Hoppe-Tichy, Torsten; Bochniarz, Marcin; Frontini, Roberto; Schwartz, David G; Vujic-Aleksic, Vesna; Nezic, Lana; Rinaki, Eleni; Tzimis, Leonidas; Green, Kim; Jovanic, Jelena; Caric, Bojana; Mandic, Danijela; Vilic, Katarina; Bochenek, Tomasz; Bacic Vrca, Vesna; Marusic, Srecko.
Afiliação
  • Kuruc Poje D; Pharmacy Department, General hospital "dr. Tomislav Bardek", Koprivnica, Croatia. darija_kuruc@yahoo.com.
  • Kifer D; Department of Biophysics, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
  • Huys I; Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
  • Miranda J; Departamento de Tecnologias, Escola Superior de Tecnologia e Gestão, Instituto Politécnico de Portalegre, Portalegre, Portugal.
  • Jenzer H; CERENA - Centro de Recursos Naturais e Ambiente, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
  • Miljkovic N; Berner Fachhochschule Health Professions Ernährung und Diätetik, Zürich, Switzerland.
  • Hoppe-Tichy T; Pharmacy Department, Institute of Orthopaedic Surgery "Banjica", Belgrade, Serbia.
  • Bochniarz M; Pharmacy Department, Heidelberg University Hospital, Heidelberg, Germany.
  • Frontini R; Specialist Hospital Brzozów, Podkarpackie Oncological Center, Brzozów, Poland.
  • Schwartz DG; European Association of Hospital Pharmacists (EAHP), Brussels, Belgium.
  • Vujic-Aleksic V; School of Business, Bar-Ilan University, Ramat Gan, Israel.
  • Nezic L; Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
  • Rinaki E; Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
  • Tzimis L; Hospital pharmacy, Chania General Hospital "Saint George", Crete, Chania, Greece.
  • Green K; Hospital pharmacy, Chania General Hospital "Saint George", Crete, Chania, Greece.
  • Jovanic J; Pharmacy Department, Heidelberg University Hospital, Heidelberg, Germany.
  • Caric B; Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
  • Mandic D; Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
  • Vilic K; Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina.
  • Bochenek T; Pharmacy Department, General hospital "dr. Tomislav Bardek", Koprivnica, Croatia.
  • Bacic Vrca V; Department of Drug Management, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland.
  • Marusic S; Pharmacy Department, Clinical hospital Dubrava, Zagreb, Croatia.
BMC Health Serv Res ; 21(1): 689, 2021 Jul 12.
Article em En | MEDLINE | ID: mdl-34253212
BACKGROUND: It is known that drug shortages represent a major challenge for all stakeholders involved in the process, but there is little evidence regarding insights into patients' awareness and perspectives. This study aimed to investigate the patients-perceived drug shortages experience and their view on outcomes in different European hospital settings. Furthermore, we wanted to explore information preferences on drug shortages. METHODS: A retrospective, cross sectional, a mixed method study was conducted in six European hospital settings. One hospital (H) from each of this country agreed to participate: Bosnia and Herzegovina (H-BiH), Croatia (H-CR), Germany (H-GE), Greece (H-GR), Serbia (H-SE) and Poland (H-PO). Recruitment and data collection was conducted over 27 months from November 2017 until January 2020. Overall, we surveyed 607 patients which completed paper-based questionnaire. Questions related to: general information (demographic data), basic knowledge on drug shortages, drug shortages experienced during hospitalization and information preferences on drug shortage. Differences between hospital settings were analyzed using Chi-squared test or Fisher's exact test. For more complex contingency tables, Monte Carlo simulations (N = 2000) were applied for Fisher's test. Post-hoc hospital-wise analyses were performed using Fisher's exact tests. False discovery rate was controlled using the Bonferroni method. Analyses were performed using R: a language and environment for statistical computing (v 3.6.3). RESULTS: 6 % of patients reported experiences with drug shortages while hospitalized which led to a deterioration of their health. The majority of affected patients were hospitalized at hematology and/or oncology wards in H-BiH, H-PO and H-GE. H-BiH had the highest number of affected patients (18.1 %, N = 19/105, p < 0.001) while the fewest patients were in H-SE (1 %, N = 1/100, p = 0.001). In addition, 82.5 %, (N = 501/607) of respondents wanted to be informed of alternative treatment options if there was a drug shortage without a generic substitute available. Majority of these patients (66.4 %, N = 386/501) prefer to be informed by a healthcare professional. CONCLUSIONS: Although drug shortages led to serious medical consequences, our findings show that most of the patients did not perceive shortages as a problem. One possible interpretation is that good hospital management practices by healthcare professionals helped to mitigate the perceived impact of shortages. Our study highlights the importance of a good communication especially between patients and healthcare professionals in whom our patients have the greatest trust.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos Genéricos / Hospitais Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: BMC Health Serv Res Assunto da revista: PESQUISA EM SERVICOS DE SAUDE Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Croácia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos Genéricos / Hospitais Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Europa Idioma: En Revista: BMC Health Serv Res Assunto da revista: PESQUISA EM SERVICOS DE SAUDE Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Croácia