Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy.
Future Sci OA
; 7(7): FSO709, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-34258022
ABSTRACT
AIM:
To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC). PATIENTS &METHODS:
213 patients were included. INCLUSION CRITERIA Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC.RESULTS:
Five-years overall survival (OS) with NPAR >18 was 34.06% (95% CI 18.3-50.5) and 65.37% (95% CI 52.4-75.6) with NPAR <18. Five years cancer-specific survival (CSS) with NPAR >18 was 42.9% (95% CI 23.9-60.7) and 74.5% (95% CI 62.6-83.1) with NPAR <18 (p < 0.001). In multivariable analysis, NPAR increased OS of 1.3 points and CSS of 4.37 points.CONCLUSION:
High NPAR prior to NAC seems to be a strong predictor of OS and CSS in MIBC patients treated with NAC and RC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Future Sci OA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália