Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K.
Front Med (Lausanne)
; 8: 697605, 2021.
Article
em En
| MEDLINE
| ID: mdl-34262921
ABSTRACT
COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Front Med (Lausanne)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Colômbia