Prevalence of human leukocyte antigen HLA-B*57:01 in individuals with HIV in West and Central Africa.
BMC Immunol
; 22(1): 48, 2021 07 22.
Article
em En
| MEDLINE
| ID: mdl-34294032
ABSTRACT
BACKGROUND:
The presence of the human leukocyte antigen HLA-B*5701 is associated with the development of a hypersensitivity reaction to abacavir (ABC). Limited data exist on HLA-B*5701 prevalence in individuals with HIV-1 in Africa. This study aimed to estimate HLA-B*5701 prevalence in individuals with HIV-1 in West and Central Africa.METHODS:
A cross-sectional study was conducted in four countries in West and central Africa (Burkina-Faso, Côte d'Ivoire, Gabon, and Togo) from January 2016 to February 2020 to determine the status of HLA-B*5701 in adults with HIV-1. The presence of HLA-B*5701 was determined by using Single Specific Primer-Polymerase Chain Reaction (SSP-PCR) in blood samples. Prevalence rates were stratified based on country.RESULTS:
A total of 4016 (69.8% women) individuals with HIV were enrolled. Their median age was 45, and the interquartile range was 38-52. We included 500 (12.4%) patients in Burkina-Faso, 1453 (36.2%) in Côte d'Ivoire, 951 (23.7%) in Gabon, and 1112 (27.7%) in Togo. The overall HLA-B*5701 prevalence was 0.1% [95% CI 0.0-0.2%]. The prevalence of HLA-B*5701 was similar according to the four countries. Only one case was reported in each country except Togo, with no cases.CONCLUSIONS:
HLA-B*5701 prevalence is low in individuals with HIV in West and central Africa, and there is no difference among countries. This study does not confirm the utility of HLA-B*5701 allele testing for abacavir use in this region.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Didesoxinucleosídeos
/
Antígenos HLA-B
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Infecções por HIV
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HIV-1
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Fármacos Anti-HIV
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Hipersensibilidade a Drogas
/
Genótipo
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
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Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
BMC Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Togo