Drugging the 'undruggable'. Therapeutic targeting of protein-DNA interactions with the use of computer-aided drug discovery methods.

Radaeva, Mariia; Ton, Anh-Tien; Hsing, Michael; Ban, Fuqiang; Cherkasov, Artem

Radaeva, Mariia; Ton, Anh-Tien; Hsing, Michael; Ban, Fuqiang; Cherkasov, Artem.

Afiliação

Radaeva M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Ton AT; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Hsing M; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Ban F; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Cherkasov A; Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada. Electronic address: acherkasov@prostatecentre.com.

Drug Discov Today ; 26(11): 2660-2679, 2021 11.

Article em En | MEDLINE | ID: mdl-34332092

Assuntos

Antineoplásicos/uso terapêutico; DNA/metabolismo; Desenho de Fármacos; Neoplasias/tratamento farmacológico; Fatores de Transcrição/metabolismo; Proteínas de Ligação a DNA/metabolismo; Humanos; Terapia de Alvo Molecular; Neoplasias/genética

Palavras-chave

AI; Cancer; Computer-aided drug discovery; Drugs; ProteinDNA interactions; Transcription factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / DNA / Desenho de Fármacos / Neoplasias / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Drug Discov Today Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

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