The input of GATA-3 in the identification of parathyroid carcinoma diagnosis: Case report with review of literature.
Ann Med Surg (Lond)
; 68: 102571, 2021 Aug.
Article
em En
| MEDLINE
| ID: mdl-34345427
ABSTRACT
INTRODUCTION:
and Importance Parathyroid carcinoma is an exceptional cancer, with significant morbidity and mortality, associated with parathyroid hormone (PTH) mediated hypercalcemia. CASE PRESENTATION We report a case of parathyroid carcinoma with a difficult histological diagnosis. This case illustrates the usefulness of the immunohistochemical marker "GATA-3" in parathyroid differentiation especially in tumours. CLINICALDISCUSSION:
The diagnosis of parathyroid carcinoma is challenging without the knowledge of the clinical information, laboratory finding, and radiographic imaging studies. The immunohistochemistry is useful tool in these cases to identify the parathyroid origin of neoplasia. GATA-3 is a transcription factor that is involved in the embryonic development of the parathyroid glands and in adult parathyroid cell proliferation.CONCLUSION:
It is concluded that GATA-3 is a very sensitive and relatively specific immunohistochemical marker for parathyroid differentiation that can assist in the differential diagnosis of parathyroid tumours.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Ann Med Surg (Lond)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Tunísia