Ending on a sour note: Lipids orchestrate ferroptosis in cancer.

Lange, Mike; Olzmann, James A

Lange, Mike; Olzmann, James A.

Afiliação

Lange M; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Olzmann JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: olzmann@berkeley.edu.

Cell Metab ; 33(8): 1507-1509, 2021 08 03.

Article em En | MEDLINE | ID: mdl-34348094

ABSTRACT

ABSTRACT

Lipid metabolism is altered in the acidic tumor microenvironment. Here, the authors show that polyunsaturated fatty acid supplementation, together with concomitant inhibition of lipid droplet biogenesis, induces ferroptosis in acidic cancer cells. These findings highlight the potential to exploit cancer dependence on exogenous lipids as a therapeutic vulnerability.

Assuntos

Ferroptose; Neoplasias; Humanos; Metabolismo dos Lipídeos; Lipídeos; Microambiente Tumoral

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose / Neoplasias Limite: Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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