Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model.

Liu, Yajing; Yao, Jinjing; Song, Zhenpeng; Guo, Wenting; Sun, Bo; Wei, Jinhong; Estillore, John Paul; Back, Thomas G; Chen, S R Wayne

Liu, Yajing; Yao, Jinjing; Song, Zhenpeng; Guo, Wenting; Sun, Bo; Wei, Jinhong; Estillore, John Paul; Back, Thomas G; Chen, S R Wayne.

Afiliação

Liu Y; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Yao J; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, China.
Song Z; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Guo W; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Sun B; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Wei J; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Estillore JP; Medical School, Kunming University of Science and Technology, Kunming, China.
Back TG; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.
Chen SRW; Department of Physiology and Pharmacology, Cumming School of Medicine, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada.

J Neurosci Res ; 99(11): 2906-2921, 2021 11.

Article em En | MEDLINE | ID: mdl-34352124

Assuntos

Doença de Alzheimer; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Modelos Animais de Doenças; Camundongos; Camundongos Transgênicos; Canal de Liberação de Cálcio do Receptor de Rianodina/genética; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo

Palavras-chave

3xTG-AD mouse model; Alzheimer's disease; RRID:AB_2040184; RRID:AB_2313606; RRID:AB_2797642; RRID:SCR_002798; RRID:SCR_011323; RRID:SCR_013726; RRID:SCR_014289; ryanodine receptor 2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Limite: Animals Idioma: En Revista: J Neurosci Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Canadá

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