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When functional blurring becomes deleterious: Reduced system segregation is associated with less white matter integrity and cognitive decline in aging.
Pedersen, Robin; Geerligs, Linda; Andersson, Micael; Gorbach, Tetiana; Avelar-Pereira, Bárbara; Wåhlin, Anders; Rieckmann, Anna; Nyberg, Lars; Salami, Alireza.
Afiliação
  • Pedersen R; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden. Electronic address: robin.pedersen@umu.se.
  • Geerligs L; Donders Institute for Brain, Cognition and Behaviour, Radbound University, Nijmegen, the Netherlands.
  • Andersson M; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden.
  • Gorbach T; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden; Department of Statistics, Umeå School of Business, Economics and Statistics, Umeå University, Umeå, Sweden.
  • Avelar-Pereira B; Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, California, USA; Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
  • Wåhlin A; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden.
  • Rieckmann A; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden.
  • Nyberg L; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden.
  • Salami A; Department of Integrative Medical Biology, Umeå University, Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden; Aging Research Center (ARC), Karolinska Institutet and Stockholm U
Neuroimage ; 242: 118449, 2021 11 15.
Article em En | MEDLINE | ID: mdl-34358662
Healthy aging is accompanied by progressive decline in cognitive performance and concomitant changes in brain structure and functional architecture. Age-accompanied alterations in brain function have been characterized on a network level as weaker functional connections within brain networks along with stronger interactions between networks. This phenomenon has been described as age-related differences in functional network segregation. It has been suggested that functional networks related to associative processes are particularly sensitive to age-related deterioration in segregation, possibly related to cognitive decline in aging. However, there have been only a few longitudinal studies with inconclusive results. Here, we used a large longitudinal sample of 284 participants between 25 to 80 years of age at baseline, with cognitive and neuroimaging data collected at up to three time points over a 10-year period. We investigated age-related changes in functional segregation among two large-scale systems comprising associative and sensorimotor-related resting-state networks. We found that functional segregation of associative systems declines in aging with exacerbated deterioration from the late fifties. Changes in associative segregation were positively associated with changes in global cognitive ability, suggesting that decreased segregation has negative consequences for domain-general cognitive functions. Age-related changes in system segregation were partly accounted for by changes in white matter integrity, but white matter integrity only weakly influenced the association between segregation and cognition. Together, these novel findings suggest a cascade where reduced white-matter integrity leads to less distinctive functional systems which in turn contributes to cognitive decline in aging.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mapeamento Encefálico / Imageamento por Ressonância Magnética / Disfunção Cognitiva / Substância Branca / Envelhecimento Cognitivo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mapeamento Encefálico / Imageamento por Ressonância Magnética / Disfunção Cognitiva / Substância Branca / Envelhecimento Cognitivo Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2021 Tipo de documento: Article