Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia.

Seipel, Katja; Graber, Carolyn; Flückiger, Laura; Bacher, Ulrike; Pabst, Thomas

Seipel, Katja; Graber, Carolyn; Flückiger, Laura; Bacher, Ulrike; Pabst, Thomas.

Afiliação

Seipel K; Department for Biomedical Research, University of Bern, 2008 Bern, Switzerland.
Graber C; Department for Biomedical Research, University of Bern, 2008 Bern, Switzerland.
Flückiger L; Department for Biomedical Research, University of Bern, 2008 Bern, Switzerland.
Bacher U; Department of Hematology, University Hospital Bern, 3010 Bern, Switzerland.
Pabst T; Department of Medical Oncology, University Hospital Bern, 3010 Bern, Switzerland.

Int J Mol Sci ; 22(15)2021 Jul 28.

Article em En | MEDLINE | ID: mdl-34360855

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Leucemia Mieloide Aguda/tratamento farmacológico; Pirimidinas/uso terapêutico; Fator de Transcrição STAT5/antagonistas & inibidores; Tiofenos/uso terapêutico; Proteínas Supressoras de Tumor/antagonistas & inibidores; Linhagem Celular Tumoral; Proteínas de Ligação a DNA/genética; Dioxigenases; Humanos; Proteínas Proto-Oncogênicas/genética; Tirosina Quinase 3 Semelhante a fms/genética

Palavras-chave

FMS-like tyrosine kinase 3 (FLT3); acute myeloid leukemia (AML); hematological malignancies; myeloid leukemia cell differentiation protein (MCL1); signal transducer and activator of transcription 5 (STAT5); ten-eleven translocation-2 (TET2); tumor suppressor p53 (TP53)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiofenos / Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas Supressoras de Tumor / Fator de Transcrição STAT5 Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça

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