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Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors.
Wang, Xintong; Xiao, Haoran; Wang, Jing; Huang, Zongze; Peng, Geng; Xie, Wenjun; Bian, Xiling; Liu, Huijie; Shi, Cheng; Yang, Taoyi; Li, Xin; Gao, Jian; Meng, Ying; Jiang, Qianchen; Chen, Wei; Hu, Fang; Wei, Ningning; Wang, Xiaowei; Zhang, Liangren; Wang, KeWei; Sun, Qi.
Afiliação
  • Wang X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Xiao H; Department of Molecualr and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Wang J; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Huang Z; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China.
  • Peng G; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Xie W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Bian X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Liu H; Department of Molecualr and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Shi C; Department of Molecualr and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Yang T; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China.
  • Li X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Gao J; Department of Molecualr and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Meng Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Jiang Q; Department of Molecualr and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Chen W; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Hu F; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Wei N; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • Wang X; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China.
  • Zhang L; Department of Pharmacology, School of Pharmacy, Qingdao University Medical College, #1 Ningde Road, Qingdao 266073, China.
  • Wang K; Institute of Innovative Drugs, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China.
  • Sun Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
J Med Chem ; 64(16): 12379-12396, 2021 08 26.
Article em En | MEDLINE | ID: mdl-34374537
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Triazinas / Agonistas Nicotínicos / Receptor Nicotínico de Acetilcolina alfa7 Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Triazinas / Agonistas Nicotínicos / Receptor Nicotínico de Acetilcolina alfa7 Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China