COVID-19 in children and young adults with moderate/severe inborn errors of immunity in a high burden area in pre-vaccine era.
Clin Immunol
; 230: 108821, 2021 09.
Article
em En
| MEDLINE
| ID: mdl-34391937
ABSTRACT
BACKGROUND:
Information regarding inborn error of immunity (IEI) as a risk factor for severe COVID-19 is scarce. We aimed to determine if paediatric patients with moderate/severe IEI got COVID-19 at the same level as the general population, and to describe COVID-19 expression. MATERIAL ANDMETHODS:
We included patients with moderate/severe IEI aged 0-21 years old cross-sectional study (June2020) to determine the prevalence of COVID-19; prospective study (January2020-January2021) including IEI patients with COVID-19. Assays used nasopharyngeal swab SARS-CoV-2 PCR and SARS-CoV-2-specific immunoglobulins.RESULTS:
Seven from sixty-five patients tested positive (prevalence 10.7% (7%-13%)) after the first SARS-COV-2 wave and 13/15 patients diagnosed with COVID-19 had an asymptomatic/mild course.CONCLUSIONS:
In our area, prevalence of COVID-19 in moderate/severe IEI paediatric patients after the first wave was slightly higher than in the general population. The majority of patients presented a benign course, suggesting a possible protective factor related with age despite IEI.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Imunodeficiência Primária
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SARS-CoV-2
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COVID-19
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Clin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article