Data-driven analysis of the kinetics of the JAK2V617F allele burden and blood cell counts during hydroxyurea treatment of patients with polycythemia vera, essential thrombocythemia, and primary myelofibrosis.

Dam, Marc J B; Pedersen, Rasmus K; Knudsen, Trine A; Andersen, Morten; Skov, Vibe; Kjaer, Lasse; Hasselbalch, Hans C; Ottesen, Johnny T

Dam, Marc J B; Pedersen, Rasmus K; Knudsen, Trine A; Andersen, Morten; Skov, Vibe; Kjaer, Lasse; Hasselbalch, Hans C; Ottesen, Johnny T.

Afiliação

Dam MJB; Center for Mathematical Modeling - Human Health and Disease, IMFUFA, Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Pedersen RK; Center for Mathematical Modeling - Human Health and Disease, IMFUFA, Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Knudsen TA; Department of Haematology, Zealand University Hospital, Roskilde, Denmark.
Andersen M; Center for Mathematical Modeling - Human Health and Disease, IMFUFA, Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Skov V; Department of Haematology, Zealand University Hospital, Roskilde, Denmark.
Kjaer L; Department of Haematology, Zealand University Hospital, Roskilde, Denmark.
Hasselbalch HC; Department of Haematology, Zealand University Hospital, Roskilde, Denmark.
Ottesen JT; Center for Mathematical Modeling - Human Health and Disease, IMFUFA, Department of Science and Environment, Roskilde University, Roskilde, Denmark.

Eur J Haematol ; 107(6): 624-633, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34411333

Assuntos

Alelos; Antineoplásicos/uso terapêutico; Contagem de Células Sanguíneas; Hidroxiureia/uso terapêutico; Janus Quinase 2/genética; Policitemia Vera/genética; Mielofibrose Primária/genética; Trombocitemia Essencial/genética; Idoso; Antineoplásicos/administração & dosagem; Estudos de Coortes; Feminino; Humanos; Hidroxiureia/administração & dosagem; Interferon alfa-2/administração & dosagem; Cinética; Masculino; Pessoa de Meia-Idade; Policitemia Vera/sangue; Policitemia Vera/tratamento farmacológico; Mielofibrose Primária/sangue; Mielofibrose Primária/tratamento farmacológico; Trombocitemia Essencial/sangue; Trombocitemia Essencial/tratamento farmacológico

Palavras-chave

JAK2V617F; MPN; data-driven analysis; essential thrombocythemia; hydroxyurea; interferon; kinetics; mathematical modeling; myelofibrosis; myeloproliferative neoplasms; polycythemia vera

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Policitemia Vera / Contagem de Células Sanguíneas / Alelos / Janus Quinase 2 / Mielofibrose Primária / Trombocitemia Essencial / Hidroxiureia / Antineoplásicos Tipo de estudo: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Haematol Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca

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