Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity.
Nat Metab
; 3(8): 1042-1057, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34417593
ABSTRACT
Obesity and its consequences are among the greatest challenges in healthcare. The gut microbiome is recognized as a key factor in the pathogenesis of obesity. Using a mouse model, we show here that a wild-derived microbiome protects against excessive weight gain, severe fatty liver disease and metabolic syndrome during a 10-week course of high-fat diet. This phenotype is transferable only during the first weeks of life. In adult mice, neither transfer nor severe disturbance of the wild-type microbiome modifies the metabolic response to a high-fat diet. The protective phenotype is associated with increased secretion of metabolic hormones and increased energy expenditure through activation of brown adipose tissue. Thus, we identify a microbiome that protects against weight gain and its negative consequences through metabolic programming in early life. Translation of these results to humans may identify early-life therapeutics that protect against obesity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dieta
/
Suscetibilidade a Doenças
/
Exposição Ambiental
/
Resistência à Doença
/
Microbiota
/
Interações entre Hospedeiro e Microrganismos
/
Obesidade
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Metab
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos