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Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors.
Si, Dongjuan; Luo, Huijuan; Zhang, Xiaomeng; Yang, Kundi; Wen, Hongmei; Li, Wei; Liu, Jian.
Afiliação
  • Si D; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Luo H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Zhang X; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Yang K; Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.
  • Wen H; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Li W; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: liwaii@njucm.edu.cn.
  • Liu J; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address: liujian623@njucm.edu.cn.
Bioorg Chem ; 115: 105268, 2021 10.
Article em En | MEDLINE | ID: mdl-34426149
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinonas / Desenho de Fármacos / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinonas / Desenho de Fármacos / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China