Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia.

Santos-Molina, Luis; Herrerias, Alexa; Zawatsky, Charles N; Gunduz-Cinar, Ozge; Cinar, Resat; Iyer, Malliga R; Wood, Casey M; Lin, Yuhong; Gao, Bin; Kunos, George; Godlewski, Grzegorz

Santos-Molina, Luis; Herrerias, Alexa; Zawatsky, Charles N; Gunduz-Cinar, Ozge; Cinar, Resat; Iyer, Malliga R; Wood, Casey M; Lin, Yuhong; Gao, Bin; Kunos, George; Godlewski, Grzegorz.

Afiliação

Santos-Molina L; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Herrerias A; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Zawatsky CN; Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Gunduz-Cinar O; Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Cinar R; Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Iyer MR; Section on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Wood CM; Section on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Lin Y; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Gao B; Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Kunos G; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Godlewski G; Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

Molecules ; 26(16)2021 Aug 22.

Article em En | MEDLINE | ID: mdl-34443679

Assuntos

Consumo de Bebidas Alcoólicas/patologia; Antagonistas de Receptores de Canabinoides/farmacologia; Endotoxemia/patologia; Etanol/efeitos adversos; Óxido Nítrico Sintase Tipo II/antagonistas & inibidores; Receptor CB1 de Canabinoide/antagonistas & inibidores; Consumo de Bebidas Alcoólicas/sangue; Animais; Ansiedade/sangue; Ansiedade/complicações; Comportamento Animal/efeitos dos fármacos; Catalepsia/induzido quimicamente; Catalepsia/complicações; Cicloexanóis/administração & dosagem; Teste de Labirinto em Cruz Elevado; Endotoxemia/sangue; Endotoxemia/complicações; Endotoxinas/sangue; Trato Gastrointestinal/efeitos dos fármacos; Trato Gastrointestinal/metabolismo; Hipotermia Induzida; Camundongos Endogâmicos C57BL; Óxido Nítrico Sintase Tipo II/metabolismo; Pirazóis/administração & dosagem; Receptor CB1 de Canabinoide/metabolismo; Rimonabanto/administração & dosagem; Rimonabanto/farmacologia; Estereoisomerismo; Sulfonamidas/administração & dosagem

Palavras-chave

CB1 receptor antagonist; MRI-1867; alcohol craving; cannabinoid; drinking in the dark; hybrid ligand; iNOS inhibitor; intracerebroventricular administration; rimonabant; two-bottle paradigm

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Endotoxemia / Receptor CB1 de Canabinoide / Etanol / Óxido Nítrico Sintase Tipo II / Antagonistas de Receptores de Canabinoides Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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