Mild and Chemoselective Phosphorylation of Alcohols Using a &#936;-Reagent.

Ociepa, Michal; Knouse, Kyle W; He, David; Vantourout, Julien C; Flood, Dillon T; Padial, Natalia M; Chen, Jason S; Sanchez, Brittany B; Sturgell, Emily J; Zheng, Bin; Qiu, Shenjie; Schmidt, Michael A; Eastgate, Martin D; Baran, Phil S

Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent.

Ociepa, Michal; Knouse, Kyle W; He, David; Vantourout, Julien C; Flood, Dillon T; Padial, Natalia M; Chen, Jason S; Sanchez, Brittany B; Sturgell, Emily J; Zheng, Bin; Qiu, Shenjie; Schmidt, Michael A; Eastgate, Martin D; Baran, Phil S.

Afiliação

Ociepa M; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Knouse KW; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
He D; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Vantourout JC; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Flood DT; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Padial NM; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Chen JS; Automated Synthesis Facility, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Sanchez BB; Automated Synthesis Facility, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Sturgell EJ; Automated Synthesis Facility, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Zheng B; Chemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.
Qiu S; Chemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.
Schmidt MA; Chemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.
Eastgate MD; Chemical Process Development, Bristol Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08901, United States.
Baran PS; Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Org Lett ; 23(24): 9337-9342, 2021 12 17.

Article em En | MEDLINE | ID: mdl-34499517

RESUMO

An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the Ψ-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to obtain.

Assuntos

Álcoois

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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