PhosphoFlowSeq - A High-throughput Kinase Activity Assay for Screening Drug Resistance Mutations in EGFR.

Wagner, Anja; Teufl, Magdalena; Gold, Lukas; Lehner, Manfred; Obinger, Christian; Sykacek, Peter; Traxlmayr, Michael W

Wagner, Anja; Teufl, Magdalena; Gold, Lukas; Lehner, Manfred; Obinger, Christian; Sykacek, Peter; Traxlmayr, Michael W.

Afiliação

Wagner A; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria; Department of Biotechnology, Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Teufl M; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Gold L; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Lehner M; St. Anna Children's Cancer Research Institute, Vienna, Austria; Department of Pediatrics, St. Anna Kinderspital, Medical University of Vienna, Vienna, Austria.
Obinger C; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Sykacek P; Department of Biotechnology, Institute for Computational Biology, University of Natural Resources and Life Sciences, Vienna, Austria.
Traxlmayr MW; Department of Chemistry, Institute of Biochemistry, University of Natural Resources and Life Sciences, Vienna, Austria. Electronic address: michael.traxlmayr@boku.ac.at.

J Mol Biol ; 433(22): 167210, 2021 11 05.

Article em En | MEDLINE | ID: mdl-34499921

Assuntos

Resistencia a Medicamentos Antineoplásicos/genética; Ensaios de Triagem em Larga Escala/métodos; Mutação; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/genética; Receptores ErbB/metabolismo; Cloridrato de Erlotinib/farmacologia; Células HEK293; Humanos; Taxa de Mutação; Fosforilação/genética; Inibidores de Proteínas Quinases/farmacologia

Palavras-chave

drug resistance screen; epidermal growth factor receptor (EGFR); erlotinib; kinase activity; tyrosine kinase inhibitor (TKI)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Ensaios de Triagem em Larga Escala / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Humans Idioma: En Revista: J Mol Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Áustria

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