Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus.
Neuron
; 109(22): 3688-3698.e6, 2021 11 17.
Article
em En
| MEDLINE
| ID: mdl-34506724
ABSTRACT
We learn and remember multiple new experiences throughout the day. The neural principles enabling continuous rapid learning and formation of distinct representations of numerous sequential experiences without major interference are not understood. To understand this process, here we interrogated ensembles of hippocampal place cells as rats explored 15 novel linear environments interleaved with sleep sessions over continuous 16 h periods. Remarkably, we found that a population of place cells were selective to environment orientation and topology. This orientation selectivity property biased the network-level discrimination and re/mapping between multiple environments. Novel environmental representations emerged rapidly as more generic, but repeated experience within the environments subsequently enhanced their discriminability. Generalization of prior experience with different environments consequently improved network predictability of future novel environmental representations via strengthened generative predictive codes. These coding schemes reveal a high-capacity, high-efficiency neuronal framework for rapid representation of numerous sequential experiences with optimal discrimination-generalization balance and reduced interference.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células de Lugar
/
Memória
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos