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Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.
Sturbaut, Manon; Bailly, Fabrice; Coevoet, Mathilde; Sileo, Pasquale; Pugniere, Martine; Liberelle, Maxime; Magnez, Romain; Thuru, Xavier; Chartier-Harlin, Marie-Christine; Melnyk, Patricia; Gelin, Muriel; Allemand, Frédéric; Guichou, Jean-François; Cotelle, Philippe.
Afiliação
  • Sturbaut M; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Bailly F; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Coevoet M; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Sileo P; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Pugniere M; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194 - ICM, UM 208 rue des Apothicaires, F-34298, Montpellier Cedex 5, France.
  • Liberelle M; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Magnez R; Univ. Lille, CNRS, Inserm, CHU Lille, IRCL, UMR9020 - UMR1277 - Canther - Cancer Heterogeneity, Plasticity and Resistance to Therapies, Platform of Integrative Chemical Biology, F-59000, Lille, France.
  • Thuru X; Univ. Lille, CNRS, Inserm, CHU Lille, IRCL, UMR9020 - UMR1277 - Canther - Cancer Heterogeneity, Plasticity and Resistance to Therapies, Platform of Integrative Chemical Biology, F-59000, Lille, France.
  • Chartier-Harlin MC; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Melnyk P; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France.
  • Gelin M; Centre de Biologie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier, France.
  • Allemand F; Centre de Biologie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier, France.
  • Guichou JF; Centre de Biologie Structurale (CBS), CNRS, INSERM, Univ Montpellier, Montpellier, France. Electronic address: guichou@cbs.cnrs.fr.
  • Cotelle P; Univ Lille, INSERM, CHU Lille, UMR-S 1172, Lille Neuroscience and Cognition Research Center, F-59000, Lille, France; ENSCL-Centrale Lille, CS 90108, F-59652, Villeneuve d'Ascq Cedex, France. Electronic address: philippe.cotelle@univ-lille.fr.
Eur J Med Chem ; 226: 113835, 2021 Dec 15.
Article em En | MEDLINE | ID: mdl-34509860
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Fatores de Transcrição / Proteínas de Ciclo Celular / Descoberta de Drogas / Fatores de Transcrição de Domínio TEA / Proteínas com Motivo de Ligação a PDZ com Coativador Transcricional / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Fatores de Transcrição / Proteínas de Ciclo Celular / Descoberta de Drogas / Fatores de Transcrição de Domínio TEA / Proteínas com Motivo de Ligação a PDZ com Coativador Transcricional / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França