Evaluation of the liver and blood micronucleus, and comet assay end points in a 14-day repeated-dose study with methyl carbamate and 1,3-propane sultone.

Tu, Honggang; Yu, Chunrong; Tong, Wen; Zhou, Changhui; Li, Ruowan; Huang, Pengcheng; Wang, Qingli; Chang, Yan

Tu, Honggang; Yu, Chunrong; Tong, Wen; Zhou, Changhui; Li, Ruowan; Huang, Pengcheng; Wang, Qingli; Chang, Yan.

Afiliação

Tu H; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Yu C; Preclinical Safety, Shanghai InnoStar Bio-Tech Co. Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Tong W; Preclinical Safety, Shanghai InnoStar Bio-Tech Co. Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Zhou C; Preclinical Safety, Shanghai InnoStar Bio-Tech Co. Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Li R; Preclinical Safety, Shanghai InnoStar Bio-Tech Co. Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Huang P; Preclinical Safety, Shanghai InnoStar Bio-Tech Co. Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Wang Q; Preclinical Safety, Shanghai InnoStar Bio-Tech Co. Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China.
Chang Y; Department of Pharmacology and Toxicology, Center for Drug Evaluation, National Medical Products Administration (China Food and Drug Administration), Beijing 100022, China.

Mutagenesis ; 36(6): 401-406, 2021 11 29.

Article em En | MEDLINE | ID: mdl-34516639

Assuntos

Carbamatos/toxicidade; Núcleo Celular/efeitos dos fármacos; Fígado/efeitos dos fármacos; Reticulócitos/efeitos dos fármacos; Tiofenos/toxicidade; Animais; Carcinógenos/toxicidade; Aberrações Cromossômicas; Ensaio Cometa/métodos; Dano ao DNA; Relação Dose-Resposta a Droga; Esquema de Medicação; Masculino; Testes para Micronúcleos/métodos; Ratos; Ratos Sprague-Dawley

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reticulócitos / Tiofenos / Carbamatos / Núcleo Celular / Fígado Limite: Animals Idioma: En Revista: Mutagenesis Assunto da revista: GENETICA MEDICA / SAUDE AMBIENTAL Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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