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Emergence of IncX3 Plasmid-Harboring blaNDM-5 in a Citrobacter sedlakii Isolated from Outdoor Aerosol in Wastewater Treatment Plant.
Zhou, Ziyu; Berglund, Björn; Liu, Jiaqi; Zhao, Ling; Xia, Huiyu; Zou, Huiyun; Zhao, Qian; Li, Xuewen.
Afiliação
  • Zhou Z; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Berglund B; Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
  • Liu J; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Zhao L; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Xia H; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Zou H; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Zhao Q; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Li X; Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Microb Drug Resist ; 28(2): 199-204, 2022 Feb.
Article em En | MEDLINE | ID: mdl-34520266
ABSTRACT
A carbapenem-resistant Citrobacter sedlakii strain AA2CS carrying blaNDM-5 was detected in outdoor aerosols of a wastewater treatment plant (WWTP) in China and the whole genome was sequenced subsequently. AA2CS was captured in an aerobic tank with aerosol particles of sizes ranging from 4.7 to 7.0 µm. Besides blaNDM-5, AA2CS also harbored 21 other antibiotic resistance genes and displayed a high level of resistance to ampicillin, cefotaxime, ceftazidime, tetracycline, and meropenem. BlaNDM-5 was located on the IncX3 plasmid (pCSNDM-5) with an IS3000-IS5-blaNDM-5-bleMBL-trpF-dsbD-IS26 structure. pCSNDM-5 was highly homologous to other blaNDM-5-carrying IncX3 plasmids in China and can be transferred to the Escherichia coli recipient J53. To our knowledge, this is the first report of carbapenem-resistant Enterobacteriaceae in outdoor aerosols in WWTPs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citrobacter / Farmacorresistência Bacteriana Múltipla / Águas Residuárias / Genes Bacterianos / Antibacterianos País/Região como assunto: Asia Idioma: En Revista: Microb Drug Resist Assunto da revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citrobacter / Farmacorresistência Bacteriana Múltipla / Águas Residuárias / Genes Bacterianos / Antibacterianos País/Região como assunto: Asia Idioma: En Revista: Microb Drug Resist Assunto da revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China