Ca<sup>2+</sup> sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector.

Gao, Mingjun; He, Yang; Yin, Xin; Zhong, Xiangbin; Yan, Bingxiao; Wu, Yue; Chen, Jin; Li, Xiaoyuan; Zhai, Keran; Huang, Yifeng; Gong, Xiangyu; Chang, Huizhong; Xie, Shenghan; Liu, Jiyun; Yue, Jiaxing; Xu, Jianlong; Zhang, Guiquan; Deng, Yiwen; Wang, Ertao; Tharreau, Didier; Wang, Guo-Liang; Yang, Weibing; He, Zuhua

Ca²⁺ sensor-mediated ROS scavenging suppresses rice immunity and is exploited by a fungal effector.

Gao, Mingjun; He, Yang; Yin, Xin; Zhong, Xiangbin; Yan, Bingxiao; Wu, Yue; Chen, Jin; Li, Xiaoyuan; Zhai, Keran; Huang, Yifeng; Gong, Xiangyu; Chang, Huizhong; Xie, Shenghan; Liu, Jiyun; Yue, Jiaxing; Xu, Jianlong; Zhang, Guiquan; Deng, Yiwen; Wang, Ertao; Tharreau, Didier; Wang, Guo-Liang; Yang, Weibing; He, Zuhua.

Afiliação

Gao M; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
He Y; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Yin X; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China; State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences,
Zhong X; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: xb-zhong@fafu.edu.cn.
Yan B; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Wu Y; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Chen J; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Li X; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zhai K; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Huang Y; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Gong X; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Chang H; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Xie S; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Liu J; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Yue J; Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
Xu J; Insititute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Zhang G; College of Agriculture, South China Agricultural University, Guangzhou 510642, China.
Deng Y; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Wang E; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.
Tharreau D; PHIM, CIRAD, INRAE, IRD, Montpellier SupAgro, MUSE, Montpellier Cedex 05, France.
Wang GL; Department of Plant Pathology, Ohio State University, OH 43210, USA.
Yang W; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China; CAS-JIC Center of Excellence for Plant and Microbial Sciences, Institute of Plant Physiology and
He Z; National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: zhhe@cemps.ac.cn.

Cell ; 184(21): 5391-5404.e17, 2021 10 14.

Article em En | MEDLINE | ID: mdl-34597584

ABSTRACT

ABSTRACT

Plant immunity is activated upon pathogen perception and often affects growth and yield when it is constitutively active. How plants fine-tune immune homeostasis in their natural habitats remains elusive. Here, we discover a conserved immune suppression network in cereals that orchestrates immune homeostasis, centering on a Ca2+-sensor, RESISTANCE OF RICE TO DISEASES1 (ROD1). ROD1 promotes reactive oxygen species (ROS) scavenging by stimulating catalase activity, and its protein stability is regulated by ubiquitination. ROD1 disruption confers resistance to multiple pathogens, whereas a natural ROD1 allele prevalent in indica rice with agroecology-specific distribution enhances resistance without yield penalty. The fungal effector AvrPiz-t structurally mimics ROD1 and activates the same ROS-scavenging cascade to suppress host immunity and promote virulence. We thus reveal a molecular framework adopted by both host and pathogen that integrates Ca2+ sensing and ROS homeostasis to suppress plant immunity, suggesting a principle for breeding disease-resistant, high-yield crops.

Assuntos

Cálcio/metabolismo; Sequestradores de Radicais Livres/metabolismo; Proteínas Fúngicas/metabolismo; Oryza/imunologia; Imunidade Vegetal; Proteínas de Plantas/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Sistemas CRISPR-Cas/genética; Membrana Celular/metabolismo; Resistência à Doença/genética; Modelos Biológicos; Oryza/genética; Doenças das Plantas/imunologia; Proteínas de Plantas/genética; Ligação Proteica; Estabilidade Proteica; Reprodução; Especificidade da Espécie; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitinação; Zea mays/imunologia

Palavras-chave

Ca(2+)-sensor; E3 ubiquitin ligases; ROD1; catalase; disease resistance; fungal effector; natural variation; reactive oxygen species; rice immunity; structural mimicry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Plantas / Oryza / Proteínas Fúngicas / Cálcio / Sequestradores de Radicais Livres / Espécies Reativas de Oxigênio / Imunidade Vegetal Tipo de estudo: Prognostic_studies Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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