Activation of TMEM16A Ca<sup>2+</sup>-activated Cl<sup>-</sup> channels by ROCK1/moesin promotes breast cancer metastasis.

Luo, Shuya; Wang, Hui; Bai, Lichuan; Chen, Yiwen; Chen, Si; Gao, Kuan; Wang, Huijie; Wu, Shuwei; Song, Hanbin; Ma, Ke; Liu, Mei; Yao, Fan; Fang, Yue; Xiao, Qinghuan

Activation of TMEM16A Ca²⁺-activated Cl^- channels by ROCK1/moesin promotes breast cancer metastasis.

Luo, Shuya; Wang, Hui; Bai, Lichuan; Chen, Yiwen; Chen, Si; Gao, Kuan; Wang, Huijie; Wu, Shuwei; Song, Hanbin; Ma, Ke; Liu, Mei; Yao, Fan; Fang, Yue; Xiao, Qinghuan.

Afiliação

Luo S; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Wang H; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Bai L; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Chen Y; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Chen S; Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang 110122, China.
Gao K; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Wang H; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Wu S; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Song H; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Ma K; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Liu M; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Yao F; Department of Breast Surgery and Surgical Oncology, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Fang Y; Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang 110122, China.
Xiao Q; Department of Ion Channel Pharmacology, School of Pharmacy, China Medical University, Shenyang 110122, China.

J Adv Res ; 33: 253-264, 2021 11.

Article em En | MEDLINE | ID: mdl-34603794

Assuntos

Neoplasias da Mama; Animais; Movimento Celular; Proliferação de Células; Feminino; Humanos; Camundongos; Proteínas dos Microfilamentos; Quinases Associadas a rho/genética

Palavras-chave

Cl− channel; EGFR, epidermal growth factor receptor; ER, estrogen receptor; FBS, fetal bovine serum; H&E, hematoxylin and eosin; HNSCC, head and neck squamous cell carcinoma; IHC, immunohistochemical; MFS, metastasis-free survival; Metastasis; Moesin; OS, overall survival; PR, progesterone receptor; ROCK1; ROCK1, Rho-associated, coiled-coil containing protein kinase 1; STAT3, signal transducers and activators of transcription 3; TCGA, The Cancer Genome Atlas; TMEM16A; shRNAs, small hairpin RNAs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Adv Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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