DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.

Li, Yufeng; Xu, Junyu; Lu, Yuting; Bian, Hua; Yang, Lin; Wu, Honghong; Zhang, Xinwen; Zhang, Beilei; Xiong, Maoqian; Chang, Yafei; Tang, Jie; Yang, Fan; Zhao, Lei; Li, Jing; Gao, Xin; Xia, Mingfeng; Tan, Minjia; Li, Jingya

Li, Yufeng; Xu, Junyu; Lu, Yuting; Bian, Hua; Yang, Lin; Wu, Honghong; Zhang, Xinwen; Zhang, Beilei; Xiong, Maoqian; Chang, Yafei; Tang, Jie; Yang, Fan; Zhao, Lei; Li, Jing; Gao, Xin; Xia, Mingfeng; Tan, Minjia; Li, Jingya.

Afiliação

Li Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Xu J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Lu Y; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Bian H; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.
Yang L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Wu H; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang X; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhang B; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Xiong M; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Chang Y; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Tang J; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Yang F; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Zhao L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Li J; Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
Gao X; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.
Xia M; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China; Fudan Institute for Metabolic Diseases, Shanghai 200032, China. Electronic address: dr_xiamingfeng@163.com.
Tan M; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: mjtan@simm.ac.cn.
Li J; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Ch

Cell Metab ; 33(10): 2004-2020.e9, 2021 10 05.

Article em En | MEDLINE | ID: mdl-34614409

Assuntos

Hepatopatia Gordurosa não Alcoólica; Fosfoproteínas; Proteínas Serina-Treonina Quinases; Fatores de Processamento de Serina-Arginina; Processamento Alternativo/genética; Animais; Proteínas Reguladoras de Apoptose/genética; Proteínas Reguladoras de Apoptose/metabolismo; Progressão da Doença; Humanos; Fígado/metabolismo; Camundongos; Hepatopatia Gordurosa não Alcoólica/genética; Hepatopatia Gordurosa não Alcoólica/metabolismo; Fosfoproteínas/genética; Fosfoproteínas/metabolismo; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; RNA/metabolismo; Fatores de Processamento de Serina-Arginina/genética; Fatores de Processamento de Serina-Arginina/metabolismo; Transcriptoma

Palavras-chave

Drak2; RNA alternative splicing; hepatic steatosis; mitochondrial function; mtDNA; nonalcoholic fatty liver disease; serine/arginine-rich splicing factor (SRSF)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Proteínas Serina-Treonina Quinases / Hepatopatia Gordurosa não Alcoólica / Fatores de Processamento de Serina-Arginina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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