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The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy-A National Study in Children.
Mizerska-Wasiak, Malgorzata; Such-Gruchot, Agnieszka; Cichon-Kawa, Karolina; Turczyn, Agnieszka; Maldyk, Jadwiga; Miklaszewska, Monika; Drozdz, Dorota; Firszt-Adamczyk, Agnieszka; Stankiewicz, Roman; Rybi-Szuminska, Agnieszka; Wasilewska, Anna; Szczepanska, Maria; Bienias, Beata; Sikora, Przemyslaw; Pukajlo-Marczyk, Agnieszka; Zwolinska, Danuta; Pawlak-Bratkowska, Monika; Tkaczyk, Marcin; Zachwieja, Jacek; Drozynska-Duklas, Magdalena; Zurowska, Aleksandra; Gadomska-Prokop, Katarzyna; Grenda, Ryszard; Panczyk-Tomaszewska, Malgorzata.
Afiliação
  • Mizerska-Wasiak M; Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
  • Such-Gruchot A; Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
  • Cichon-Kawa K; Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
  • Turczyn A; Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
  • Maldyk J; Department of Pathology, Medical University of Warsaw, 02-091 Warsaw, Poland.
  • Miklaszewska M; Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, 30-663 Cracow, Poland.
  • Drozdz D; Department of Pediatric Nephrology and Hypertension, Jagiellonian University Medical College, 30-663 Cracow, Poland.
  • Firszt-Adamczyk A; Department of Pediatrics and Nephrology, Ludwik Rydygier Hospital, 87-100 Torun, Poland.
  • Stankiewicz R; Department of Pediatrics and Nephrology, Ludwik Rydygier Hospital, 87-100 Torun, Poland.
  • Rybi-Szuminska A; Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-089 Bialystok, Poland.
  • Wasilewska A; Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-089 Bialystok, Poland.
  • Szczepanska M; Department of Pediatrics, SMDZ in Zabrze, Silesian Medical University, 41-808 Zabrze, Poland.
  • Bienias B; Department of Pediatric Nephrology, Medical University of Lublin, 20-059 Lublin, Poland.
  • Sikora P; Department of Pediatric Nephrology, Medical University of Lublin, 20-059 Lublin, Poland.
  • Pukajlo-Marczyk A; Department of Pediatric Nephrology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Zwolinska D; Department of Pediatric Nephrology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
  • Pawlak-Bratkowska M; Department of Pediatrics, Immunology and Nephrology, Polish Mothers Memorial Hospital Research Institute, 93-338 Lodz, Poland.
  • Tkaczyk M; Department of Pediatrics, Immunology and Nephrology, Polish Mothers Memorial Hospital Research Institute, 93-338 Lodz, Poland.
  • Zachwieja J; Department of Pediatric Nephrology and Dialysis, Medical University of Poznan, 61-701 Poznan, Poland.
  • Drozynska-Duklas M; Department of Pediatrics, Nephrology and Hypertension, Medical University of Gdansk, 80-210 Gdansk, Poland.
  • Zurowska A; Department of Pediatrics, Nephrology and Hypertension, Medical University of Gdansk, 80-210 Gdansk, Poland.
  • Gadomska-Prokop K; Department of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
  • Grenda R; Department of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, 04-730 Warsaw, Poland.
  • Panczyk-Tomaszewska M; Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, Poland.
J Clin Med ; 10(19)2021 Sep 26.
Article em En | MEDLINE | ID: mdl-34640422
ABSTRACT
The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Clin Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Clin Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia