Astrocyte interleukin-3 preps microglia.

Klein, Robyn S

Klein, Robyn S.

Afiliação

Klein RS; Center for Neuroimmunology and Neuroinfectious Diseases, Departments of Medicine, Pathology and Immunology, and Neuroscience, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: rklein@wustl.edu.

Trends Immunol ; 42(11): 937-939, 2021 11.

Article em En | MEDLINE | ID: mdl-34657802

RESUMO

Brain ß-amyloid (Aß) deposition is a biomarker for Alzheimer's disease (AD) and other dementias, in which Aß amounts correlate with disease burden. McAlpine et al. reveal that astrocyte expression or administration of interleukin (IL)-3 in the context of aggregated Aß endows microglia with enhanced capability to cluster and clear Aß oligomers.

Assuntos

Doença de Alzheimer; Microglia; Peptídeos beta-Amiloides/metabolismo; Astrócitos; Humanos; Interleucina-3/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Doença de Alzheimer Limite: Humans Idioma: En Revista: Trends Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2021 Tipo de documento: Article

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