[Autonomous cortisol secretion : Laboratory artifact or disease?] / Autonome Kortisolsekretion : Laborartefakt oder Krankheit?
Internist (Berl)
; 63(1): 18-24, 2022 Jan.
Article
em De
| MEDLINE
| ID: mdl-34709420
ABSTRACT
BACKGROUND:
Autonomous cortisol secretion was mentioned for the first time in 2016 in the European Guideline on the management of adrenal incidentalomas.OBJECTIVES:
Review of the state of knowledge on diagnosis, epidemiology, co-morbidities, mortality and treatment of autonomous cortisol secretion in comparison to non-hormone producing adenomas. Recommendation for clinical practice based on the current European guideline. MATERIALS UNDMETHODS:
Analysis of relevant clinical studies, discussion of basic literature and expert opinions. RESULTS ANDCONCLUSIONS:
Autonomous cortisol secretion is a term used to describe abnormal cortisol secretion diagnosed by a pathological 1mg dexamethasone suppression test in patients with adrenal incidentaloma, but without clinical manifestation of overt Cushing's syndrome. It is associated with increased mortality and morbidity, especially hypertension, diabetes mellitus type II, dyslipidemia and obesity. Adrenalectomy, as the only specific therapy option, should be considered in an interdisciplinary tumour board.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias das Glândulas Suprarrenais
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Qualitative_research
Limite:
Humans
Idioma:
De
Revista:
Internist (Berl)
Ano de publicação:
2022
Tipo de documento:
Article