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A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity.
Alder, Arne; Struck, Nicole S; Xu, Min; Johnson, Jarrod W; Wang, Wenliang; Pallant, Daniel; Cook, Michael A; Rambow, Janis; Lemcke, Sarah; Gilberger, Tim W; Wright, Gerard D.
Afiliação
  • Alder A; Centre for Structural Systems Biology, 22607 Hamburg, Germany; Bernhard Nocht Institute for Tropical Medicine, Department of Cellular Parasitology, 20359 Hamburg, Germany; University of Hamburg, Department of Biology, 20146 Hamburg, Germany.
  • Struck NS; Bernhard Nocht Institute for Tropical Medicine, Department of Cellular Parasitology, 20359 Hamburg, Germany; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada; German Centre for Infection Res
  • Xu M; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
  • Johnson JW; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
  • Wang W; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
  • Pallant D; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
  • Cook MA; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.
  • Rambow J; Centre for Structural Systems Biology, 22607 Hamburg, Germany; Bernhard Nocht Institute for Tropical Medicine, Department of Cellular Parasitology, 20359 Hamburg, Germany; University of Hamburg, Department of Biology, 20146 Hamburg, Germany.
  • Lemcke S; Centre for Structural Systems Biology, 22607 Hamburg, Germany; Bernhard Nocht Institute for Tropical Medicine, Department of Cellular Parasitology, 20359 Hamburg, Germany; University of Hamburg, Department of Biology, 20146 Hamburg, Germany.
  • Gilberger TW; Centre for Structural Systems Biology, 22607 Hamburg, Germany; Bernhard Nocht Institute for Tropical Medicine, Department of Cellular Parasitology, 20359 Hamburg, Germany; University of Hamburg, Department of Biology, 20146 Hamburg, Germany. Electronic address: gilberger@bnitm.de.
  • Wright GD; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address: wrightge@mcmaster.ca.
Cell Chem Biol ; 29(5): 840-853.e6, 2022 05 19.
Article em En | MEDLINE | ID: mdl-34710358
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parasitos / Produtos Biológicos / Antagonistas do Ácido Fólico / Malária / Antimaláricos Limite: Animals / Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parasitos / Produtos Biológicos / Antagonistas do Ácido Fólico / Malária / Antimaláricos Limite: Animals / Humans Idioma: En Revista: Cell Chem Biol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha