&#945;-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-ß-catenin pathway.

Zhu, Zewu; Ruan, Shuhao; Jiang, Yingcheng; Huang, Fang; Xia, Weiping; Chen, Jinbo; Cui, Yu; He, Cheng; Zeng, Feng; Li, Yang; Chen, Zhiyong; Chen, Hequn

α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-ß-catenin pathway.

Zhu, Zewu; Ruan, Shuhao; Jiang, Yingcheng; Huang, Fang; Xia, Weiping; Chen, Jinbo; Cui, Yu; He, Cheng; Zeng, Feng; Li, Yang; Chen, Zhiyong; Chen, Hequn.

Afiliação

Zhu Z; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Ruan S; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Jiang Y; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Huang F; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Xia W; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Chen J; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Cui Y; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
He C; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Zeng F; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Li Y; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
Chen Z; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. jeffastone@126.com.
Chen H; Department of Urology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. chenhequnxy@126.com.

Cell Mol Life Sci ; 78(23): 7831-7849, 2021 Dec.

Article em En | MEDLINE | ID: mdl-34724098

Assuntos

Diferenciação Celular; Fibroblastos/patologia; Cálculos Renais/patologia; Proteínas Klotho/metabolismo; Osteogênese; Proteínas Wnt/antagonistas & inibidores; beta Catenina/antagonistas & inibidores; Animais; Fibroblastos/metabolismo; Regulação da Expressão Gênica; Humanos; Peptídeos e Proteínas de Sinalização Intercelular/genética; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Cálculos Renais/genética; Cálculos Renais/metabolismo; Medula Renal/metabolismo; Medula Renal/patologia; Proteínas Klotho/genética; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Nus; Proteínas Wnt/genética; Proteínas Wnt/metabolismo; beta Catenina/genética; beta Catenina/metabolismo

Palavras-chave

HK-2; Osteogenic differentiation; Randall's plaques; Renal interstitial fibroblasts; α-Klotho; ß-catenin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Cálculos Renais / Diferenciação Celular / Proteínas Wnt / Beta Catenina / Fibroblastos / Proteínas Klotho Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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