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The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
Pan, Min; Wright, William C; Chapple, Richard H; Zubair, Asif; Sandhu, Manbir; Batchelder, Jake E; Huddle, Brandt C; Low, Jonathan; Blankenship, Kaley B; Wang, Yingzhe; Gordon, Brittney; Archer, Payton; Brady, Samuel W; Natarajan, Sivaraman; Posgai, Matthew J; Schuetz, John; Miller, Darcie; Kalathur, Ravi; Chen, Siquan; Connelly, Jon Patrick; Babu, M Madan; Dyer, Michael A; Pruett-Miller, Shondra M; Freeman, Burgess B; Chen, Taosheng; Godley, Lucy A; Blanchard, Scott C; Stewart, Elizabeth; Easton, John; Geeleher, Paul.
Afiliação
  • Pan M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Wright WC; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Chapple RH; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Zubair A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Sandhu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Batchelder JE; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Huddle BC; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Low J; The Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 10065, USA.
  • Blankenship KB; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Wang Y; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Gordon B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Archer P; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Brady SW; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Natarajan S; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Posgai MJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Schuetz J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Miller D; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Kalathur R; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, IL, 60637, USA.
  • Chen S; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Connelly JP; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Babu MM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Dyer MA; Cellular Screening Center, The University of Chicago, Chicago, IL, 60637, USA.
  • Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Freeman BB; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Chen T; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Godley LA; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA.
  • Blanchard SC; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Stewart E; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Easton J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • Geeleher P; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, IL, 60637, USA.
Nat Commun ; 12(1): 6468, 2021 11 09.
Article em En | MEDLINE | ID: mdl-34753908
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Morfolinas / DNA Topoisomerases Tipo II / Indóis / Neuroblastoma Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Morfolinas / DNA Topoisomerases Tipo II / Indóis / Neuroblastoma Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos