An Aicardi-Goutières Syndrome-Causative Point Mutation in <i>Adar1</i> Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.

Inoue, Maal; Nakahama, Taisuke; Yamasaki, Ryuichiro; Shibuya, Toshiharu; Kim, Jung In; Todo, Hiroyuki; Xing, Yanfang; Kato, Yuki; Morii, Eiichi; Kawahara, Yukio

An Aicardi-Goutières Syndrome-Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice.

Inoue, Maal; Nakahama, Taisuke; Yamasaki, Ryuichiro; Shibuya, Toshiharu; Kim, Jung In; Todo, Hiroyuki; Xing, Yanfang; Kato, Yuki; Morii, Eiichi; Kawahara, Yukio.

Afiliação

Inoue M; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Nakahama T; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yamasaki R; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Shibuya T; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kim JI; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Todo H; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Xing Y; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kato Y; Department of RNA Biology and Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan.
Morii E; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan.
Kawahara Y; Department of Pathology, Graduate School of Medicine, Osaka University, Osaka, Japan; and.

J Immunol ; 207(12): 3016-3027, 2021 12 15.

Article em En | MEDLINE | ID: mdl-34772697

Assuntos

Adenosina Desaminase; Encefalopatias; Adenosina Desaminase/genética; Adenosina Desaminase/metabolismo; Animais; Doenças Autoimunes do Sistema Nervoso; Inflamação/genética; Inflamação/metabolismo; Camundongos; Mutação; Malformações do Sistema Nervoso; Mutação Puntual; Isoformas de Proteínas/genética; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalopatias / Adenosina Desaminase Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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