Cellular retinol binding protein-1 inhibits cancer stemness via upregulating WIF1 to suppress Wnt/ß-catenin pathway in hepatocellular carcinoma.

Liu, Xiangye; Shan, Wenhua; Li, Tingting; Gao, Xiaoge; Kong, Fanyun; You, Hongjuan; Kong, Delong; Qiao, Shuxi; Tang, Renxian

Liu, Xiangye; Shan, Wenhua; Li, Tingting; Gao, Xiaoge; Kong, Fanyun; You, Hongjuan; Kong, Delong; Qiao, Shuxi; Tang, Renxian.

Afiliação

Liu X; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China. liuxy83@xzhmu.edu.cn.
Shan W; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, People's Republic of China.
Li T; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China.
Gao X; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, People's Republic of China.
Kong F; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China.
You H; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China.
Kong D; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China.
Qiao S; Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221002, People's Republic of China.
Tang R; Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China. tangrenxian-t@163.com.

BMC Cancer ; 21(1): 1224, 2021 Nov 14.

Article em En | MEDLINE | ID: mdl-34775955

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/metabolismo; Células-Tronco Neoplásicas; Proteínas Celulares de Ligação ao Retinol/metabolismo; Via de Sinalização Wnt; Animais; Carcinoma Hepatocelular/mortalidade; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Proliferação de Células; Progressão da Doença; Resistencia a Medicamentos Antineoplásicos; Feminino; Humanos; Fígado/metabolismo; Neoplasias Hepáticas/mortalidade; Neoplasias Hepáticas/patologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; Proteínas de Neoplasias/metabolismo; Receptores do Ácido Retinoico/metabolismo; Receptores X de Retinoides/metabolismo; Esferoides Celulares; Regulação para Cima; beta Catenina/metabolismo

Palavras-chave

Cancer stemness; Cellular retinol binding protein-1; Hepatocellular carcinoma; Retinoic acid; Wnt inhibitory factor 1; Wnt/ß-catenin signaling pathway

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Carcinoma Hepatocelular / Proteínas Adaptadoras de Transdução de Sinal / Proteínas Celulares de Ligação ao Retinol / Via de Sinalização Wnt / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google