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Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
Bagal, Sharan K; Gregson, Clare; O' Donovan, Daniel H; Pike, Kurt G; Bloecher, Andrew; Barton, Peter; Borodovsky, Alexandra; Code, Erin; Fillery, Shaun M; Hsu, Jessie Hao-Ru; Kawatkar, Sameer P; Li, Chengzhi; Longmire, David; Nai, Youfeng; Nash, Samuel C; Pike, Andrew; Robinson, James; Read, Jon A; Rawlins, Phillip B; Shen, Minhui; Tang, Jia; Wang, Peng; Woods, Haley; Williamson, Beth.
Afiliação
  • Bagal SK; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Gregson C; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • O' Donovan DH; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Pike KG; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Bloecher A; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Barton P; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Borodovsky A; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Code E; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Fillery SM; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Hsu JH; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Kawatkar SP; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Li C; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Longmire D; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Nai Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Nash SC; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Pike A; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Robinson J; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Read JA; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Rawlins PB; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
  • Shen M; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Tang J; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Wang P; Pharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Woods H; AstraZeneca, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.
  • Williamson B; AstraZeneca, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0AA, United Kingdom.
J Med Chem ; 64(23): 17146-17183, 2021 12 09.
Article em En | MEDLINE | ID: mdl-34807608
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Complexo Repressor Polycomb 2 Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Complexo Repressor Polycomb 2 Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido