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Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies.
Linsenmeier, Luise; Mohammadi, Behnam; Shafiq, Mohsin; Frontzek, Karl; Bär, Julia; Shrivastava, Amulya N; Damme, Markus; Song, Feizhi; Schwarz, Alexander; Da Vela, Stefano; Massignan, Tania; Jung, Sebastian; Correia, Angela; Schmitz, Matthias; Puig, Berta; Hornemann, Simone; Zerr, Inga; Tatzelt, Jörg; Biasini, Emiliano; Saftig, Paul; Schweizer, Michaela; Svergun, Dmitri; Amin, Ladan; Mazzola, Federica; Varani, Luca; Thapa, Simrika; Gilch, Sabine; Schätzl, Hermann; Harris, David A; Triller, Antoine; Mikhaylova, Marina; Aguzzi, Adriano; Altmeppen, Hermann C; Glatzel, Markus.
Afiliação
  • Linsenmeier L; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Mohammadi B; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Shafiq M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Frontzek K; Institute of Neuropathology, University of Zurich, Zürich, Switzerland.
  • Bär J; Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Shrivastava AN; Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.
  • Damme M; École Normale Supérieure, Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.
  • Song F; Institute of Biochemistry, Christian Albrechts University, Kiel, Germany.
  • Schwarz A; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
  • Da Vela S; Institute of Nanostructure and Solid State Physics, Universität Hamburg, Hamburg, Germany.
  • Massignan T; European Molecular Biology Laboratory (EMBL), Hamburg, Germany.
  • Jung S; Dulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.
  • Correia A; Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.
  • Schmitz M; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
  • Puig B; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
  • Hornemann S; Department of Neurology, Experimental Research in Stroke and Inflammation, UKE, Hamburg, Germany.
  • Zerr I; Institute of Neuropathology, University of Zurich, Zürich, Switzerland.
  • Tatzelt J; Department of Neurology, University Medical Center Göttingen, Göttingen, Germany.
  • Biasini E; Department Biochemistry of Neurodegenerative Diseases, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.
  • Saftig P; Cluster of Excellence RESOLV, Bochum, Germany.
  • Schweizer M; Dulbecco Telethon Laboratory of Prions and Amyloids, CIBIO, University of Trento, Trento, Italy.
  • Svergun D; Institute of Biochemistry, Christian Albrechts University, Kiel, Germany.
  • Amin L; Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.
  • Mazzola F; European Molecular Biology Laboratory (EMBL), Hamburg, Germany.
  • Varani L; Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
  • Thapa S; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
  • Gilch S; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
  • Schätzl H; Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
  • Harris DA; Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
  • Triller A; Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
  • Mikhaylova M; Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.
  • Aguzzi A; École Normale Supérieure, Institut de Biologie de l'ENS (IBENS), INSERM, CNRS, PSL Research University, Paris, France.
  • Altmeppen HC; Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
  • Glatzel M; Center for Molecular Neurobiology Hamburg (ZMNH), UKE, Hamburg, Germany.
Sci Adv ; 7(48): eabj1826, 2021 Nov 26.
Article em En | MEDLINE | ID: mdl-34818048
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Sci Adv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Sci Adv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha