[Penile intraepithelial neoplasia]. / Les néoplasies intraépithéliales peniennes.

ABSTRACT

Penile carcinogenesis can be superposed on vulvar carcinogenesis, with two pathways  with or without a link to HPV. Penile squamous cell carcinomas arise from precursor lesions penile intraepithelial neoplasia (PeIN) defined by the presence of intraepithelial atypia, which can progress to invasive squamous cell carcinoma. Differentiated PeINs not linked to HPV, affect elderly men with inflammatory lesions, most often lichen sclerosus. PeINs linked to HPV, basaloid, condylomatous or condylomatous-basaloid growth affect younger men. Although clinically similar, their distinction is important, because the treatment differs with a greater risk of invasion for forms unrelated to HPV.