Total syntheses of ericifolione and its analogues via a biomimetic inverse-electron-demand Diels-Alder reaction.
Chem Commun (Camb)
; 58(2): 270-273, 2021 Dec 23.
Article
em En
| MEDLINE
| ID: mdl-34878459
ABSTRACT
Driven by bioinspiration and appreciation of the structure of ericifolione, a biomimetic tautomerization/intermolecular inverse-electron-demand hetero Diels-Alder reaction cascade sequence promoted by sodium acetate to rapidly construct sterically hindered dihydropyran scaffolds was established, which allowed the first straightforward biomimetic total syntheses of ericifolione and its analogues with high simplicity. Moreover, this methodology set the stage for the preparation of relevant natural products or derivatives.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article