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The incidence of symptomatic osteonecrosis is similar between Japanese children and children in Western countries with acute lymphoblastic leukaemia treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol.
Moriya, Kunihiko; Imamura, Toshihiko; Katayama, Saori; Kaino, Akira; Okamoto, Kenji; Yokoyama, Norihumi; Uemura, Suguru; Kitazawa, Hironobu; Sekimizu, Masahiro; Hiramatsu, Hidefumi; Usami, Ikuya; Ishida, Hisashi; Hasegawa, Daiichiro; Hama, Asahito; Moriya-Saito, Akiko; Sato, Atsushi; Sasahara, Yoji; Suenobu, Souichi; Horibe, Keizo; Hara, Junichi.
Afiliação
  • Moriya K; Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Imamura T; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Katayama S; Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kaino A; Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Okamoto K; Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Yokoyama N; Department of Pediatrics, Gifu City Hospital, Gifu, Japan.
  • Uemura S; Department of Hematology/Oncology, Hyogo Prefectural Children's Hospital, Kobe, Japan.
  • Kitazawa H; Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Aichi Medical Center Nagoya First Hospital, Nagoya, Japan.
  • Sekimizu M; Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • Hiramatsu H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Usami I; Department of Pediatric Hematology and Oncology, Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Japan.
  • Ishida H; Department of Pediatrics, Okayama University Hospital, Okayama, Japan.
  • Hasegawa D; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • Hama A; Department of Hematology/Oncology, Hyogo Prefectural Children's Hospital, Kobe, Japan.
  • Moriya-Saito A; Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Aichi Medical Center Nagoya First Hospital, Nagoya, Japan.
  • Sato A; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
  • Sasahara Y; Department of Hematology/Oncology, Miyagi Children's Hospital, Sendai, Japan.
  • Suenobu S; Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Horibe K; Department of Pediatrics, Faculty of Medicine, Oita University, Yufu, Japan.
  • Hara J; Department of Pediatrics, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Br J Haematol ; 196(5): 1257-1261, 2022 03.
Article em En | MEDLINE | ID: mdl-34879431
ABSTRACT
In this study, we performed a retrospective analysis of a cohort of Japanese paediatric patients with B-cell precursor (BCP)-acute lymphoblastic leukaemia (ALL) treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol, to clarify the incidence, clinical characteristics, and risk factors of osteonecrosis (ON) in comparison to the ALL-02 protocol. We identified a high frequency of ON with the BFM95-based protocol compared to the ALL-02 protocol. The incidence of symptomatic ON with the BFM95-based protocol is comparable to previous studies in Western countries. We believe that the type of treatment regimen has more impact on the incidence of symptomatic ON in paediatric ALL than ethnicity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteonecrose / Protocolos de Quimioterapia Combinada Antineoplásica / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Diagnostic_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Asia Idioma: En Revista: Br J Haematol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteonecrose / Protocolos de Quimioterapia Combinada Antineoplásica / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Diagnostic_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male País/Região como assunto: Asia Idioma: En Revista: Br J Haematol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão