Engineered bacteria recycle tumor metabolic waste to boost immunotherapy.

Cubillos-Ruiz, Juan R; Cubillos-Ruiz, Andres

Cubillos-Ruiz, Juan R; Cubillos-Ruiz, Andres.

Afiliação

Cubillos-Ruiz JR; Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: jur2016@med.cornell.edu.
Cubillos-Ruiz A; Institute for Medical Engineering and Science, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: andres.cubillos@wyss.harvard.edu.

Cell Host Microbe ; 29(12): 1725-1727, 2021 12 08.

Article em En | MEDLINE | ID: mdl-34883059

ABSTRACT

ABSTRACT

A recent study published in Nature by Canale et al. (2021) shows that engineered probiotic bacteria can be used to augment the availability of nutrients required for optimal immune cell function in tumors. This approach enhances anti-tumor immunity and improves the efficacy of immunotherapy in mouse models of cancer.

Assuntos

Bactérias/metabolismo; Imunização Secundária; Imunoterapia; Engenharia Metabólica; Neoplasias/metabolismo; Animais; Bactérias/genética; Modelos Animais de Doenças; Camundongos; Nutrientes; Probióticos; Microambiente Tumoral/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bactérias / Imunização Secundária / Engenharia Metabólica / Imunoterapia / Neoplasias Limite: Animals Idioma: En Revista: Cell Host Microbe Assunto da revista: MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article

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