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Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation.
Liu, Xingyun; Chang, Xinyu; Wu, Qin; Xu, Jun; Chen, Lu; Shen, Ruiting; Hou, Xiaolin.
Afiliação
  • Liu X; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
  • Chang X; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
  • Wu Q; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
  • Xu J; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
  • Chen L; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
  • Shen R; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China.
  • Hou X; Livestock and Poultry Healthy Breeding Research Sub-center of Biochip Beijing Engineering Research Center, Department of Veterinary Medicine, Beijing University of Agriculture, Beijing, People's Republic of China. Electronic address: hxlsx@163.com.
Microb Pathog ; 162: 105352, 2022 Jan.
Article em En | MEDLINE | ID: mdl-34883226
ABSTRACT
Avian infectious bronchitis (IB) was caused by infectious bronchitis virus (IBV), a coronavirus, which leads to enormous economic losses in the poultry industry. Studies have shown that lithium chloride (LiCl) is a good virus inhibitor. Through cell culture, virus infection, and RT-qPCR, we found that LiCl could down-regulate the apoptosis-related genes Caspase-3 and Bax, up-regulate Bcl-2, and down-regulate the inflammatory-related genes (NF-κB, NLRP3, TNF-α, and IL-1ß) via inhibiting virus replication. Finally, clinical trials showed that LiCl could inhibit IBV-induced apoptosis and inflammatory in chicken embryos as well as reduce the mortality and deformity rate of chicken embryos. The results showed that LiCl has antiviral activity against IBV and clinical effects. Further studies are required to explore the exact action mechanism of LiCl on IBV-induced apoptosis and inflammation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Aves Domésticas / Vírus da Bronquite Infecciosa Limite: Animals Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Aves Domésticas / Vírus da Bronquite Infecciosa Limite: Animals Idioma: En Revista: Microb Pathog Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2022 Tipo de documento: Article