TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.

Etwebi, Zienab; Goldsmith, Jason R; Bou-Dargham, Mayassa; Tian, Yuhua; Hood, Ryan; Spitofsky, Nina; Li, Mingyue; Sun, Honghong; Lou, Yunwei; Liu, Suxia; Lengner, Christopher; Chen, Youhai H

Etwebi, Zienab; Goldsmith, Jason R; Bou-Dargham, Mayassa; Tian, Yuhua; Hood, Ryan; Spitofsky, Nina; Li, Mingyue; Sun, Honghong; Lou, Yunwei; Liu, Suxia; Lengner, Christopher; Chen, Youhai H.

Afiliação

Etwebi Z; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Goldsmith JR; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bou-Dargham M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tian Y; Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.
Hood R; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Spitofsky N; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Li M; Wistar Institute, Philadelphia PA, USA.
Sun H; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lou Y; Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University, Xinxiang, China.
Liu S; Institute of Immunology, Shandong University School of Medicine, Jinan, China.
Lengner C; Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.
Chen YH; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Inflamm Bowel Dis ; 28(5): 764-774, 2022 05 04.

Article em En | MEDLINE | ID: mdl-34894222

TIPE2 (TNF-alpha-induced protein 8-like 2) regulates immune function. Here, we find that it differentially regulates the initiation and progression of its immunoregulatory properties affect murine colitis-associated colon cancer initiation and progression. Surprisingly, we found that TIPE2 a novel tumor suppressor in enterocytes, a cell compartment it was not previously known to directly regulate.

Assuntos

Neoplasias Associadas a Colite; Colite; Doenças Inflamatórias Intestinais; Animais; Azoximetano/toxicidade; Transformação Celular Neoplásica/patologia; Colite/induzido quimicamente; Colite/complicações; Neoplasias Associadas a Colite/genética; Colo/patologia; Sulfato de Dextrana/toxicidade; Modelos Animais de Doenças; Inflamação/patologia; Doenças Inflamatórias Intestinais/complicações; Peptídeos e Proteínas de Sinalização Intracelular/genética; Camundongos; Camundongos Endogâmicos C57BL

Palavras-chave

IL-22; TIPE2; colitis-associated colon cancer; tumor suppressor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite / Neoplasias Associadas a Colite Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Inflamm Bowel Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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