Inhibition of cotranslational translocation by apratoxin S4: Effects on oncogenic receptor tyrosine kinases and the fate of transmembrane proteins produced in the cytoplasm.

Cai, Weijing; Ratnayake, Ranjala; Wang, Mengxiong; Chen, Qi-Yin; Raisch, Kevin P; Dang, Long H; Law, Brian K; Luesch, Hendrik

Cai, Weijing; Ratnayake, Ranjala; Wang, Mengxiong; Chen, Qi-Yin; Raisch, Kevin P; Dang, Long H; Law, Brian K; Luesch, Hendrik.

Afiliação

Cai W; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Ratnayake R; Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, FL, 32610, USA.
Wang M; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Chen QY; Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, FL, 32610, USA.
Raisch KP; Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Dang LH; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
Law BK; Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, FL, 32610, USA.
Luesch H; Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, 32610, USA.

Curr Res Pharmacol Drug Discov ; 2: 100053, 2021.

Article em En | MEDLINE | ID: mdl-34909679

Palavras-chave

CDCP1; Cotranslational translocation; KRAS; N-glycosylation; RTK inhibitors; Sec61

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Curr Res Pharmacol Drug Discov Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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