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Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model.
Sharma, Ruchi; George, Aman; Nimmagadda, Malika; Ortolan, Davide; Karla, Barbosa-Sabanero; Qureshy, Zoya; Bose, Devika; Dejene, Roba; Liang, Genqing; Wan, Qin; Chang, Justin; Jha, Balendu Shekhar; Memon, Omar; Miyagishima, Kiyoharu Joshua; Rising, Aaron; Lal, Madhu; Hanson, Eric; King, Rebecca; Campos, Mercedes Maria; Ferrer, Marc; Amaral, Juan; McGaughey, David; Bharti, Kapil.
Afiliação
  • Sharma R; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • George A; Pediatric, Developmental, & Genetic Ophthalmology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Nimmagadda M; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Ortolan D; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Karla BS; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Qureshy Z; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Bose D; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Dejene R; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Liang G; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Wan Q; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Chang J; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Jha BS; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Memon O; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Miyagishima KJ; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Rising A; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Lal M; Research Governance Council, FDA, White Oak, MD, USA.
  • Hanson E; Intramural Research Program, NIAMS, National Institutes of Health, Bethesda, MD, 20892, USA.
  • King R; Division of Preclinical Innovation, NCATS, National Institutes of Health, Rockville, MD, 20850, USA.
  • Campos MM; Histology Core, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Ferrer M; Division of Preclinical Innovation, NCATS, National Institutes of Health, Rockville, MD, 20850, USA.
  • Amaral J; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • McGaughey D; Ophthalmic Genetics and Visual Functions Branch, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Bharti K; Ocular and Stem Cell Translational Research Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 20892, USA. Kapil.Bharti@nih.gov.
Nat Commun ; 12(1): 7293, 2021 12 15.
Article em En | MEDLINE | ID: mdl-34911940
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Epitélio Pigmentado da Retina / Células-Tronco Pluripotentes Induzidas / Ácido Aminocaproico / Degeneração Macular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Pirróis / Epitélio Pigmentado da Retina / Células-Tronco Pluripotentes Induzidas / Ácido Aminocaproico / Degeneração Macular Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos