Improved Photodynamic Activity of Phthalocyanine by Adjusting the Chirality of Modified Amino Acids.
Mol Pharm
; 19(1): 115-123, 2022 01 03.
Article
em En
| MEDLINE
| ID: mdl-34927440
ABSTRACT
Herein, four zinc phthalocyanines (ZnPcs) with chiral lysine modification were synthesized. We found that the chirality of lysine and the chiral structure position strongly influence the properties of ZnPcs. Among the four ZnPcs, d-lysine-modified ZnPc through -NH2 on Cε [denoted N(ε)-d-lys-ZnPc] showed superior properties, including tumor enrichment, cancer cell uptake, and tumor retention capability, compared to the other three ZnPcs. Thus, chiral molecule modification is a simple and effective strategy to regulate the abovementioned properties to achieve a satisfactory antitumor outcome of drugs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estereoisomerismo
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Fármacos Fotossensibilizantes
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Isoindóis
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Aminoácidos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Mol Pharm
Assunto da revista:
BIOLOGIA MOLECULAR
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FARMACIA
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FARMACOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China