Interpreting the Physicochemical Meaning of a Molecular Descriptor Which Is Predictive of Amorphous Solid Dispersion Formation in Polyvinylpyrrolidone Vinyl Acetate.

DeBoyace, Kevin; Bookwala, Mustafa; Buckner, Ira S; Zhou, Deliang; Wildfong, Peter L D

DeBoyace, Kevin; Bookwala, Mustafa; Buckner, Ira S; Zhou, Deliang; Wildfong, Peter L D.

Afiliação

DeBoyace K; School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Bookwala M; School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Buckner IS; School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.
Zhou D; Drug Product Development, Research and Development, 1 North Waukegan Road, North Chicago, Illinois 60064, United States.
Wildfong PLD; School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, United States.

Mol Pharm ; 19(1): 303-317, 2022 01 03.

Article em En | MEDLINE | ID: mdl-34932358

Assuntos

Composição de Medicamentos/métodos; Liberação Controlada de Fármacos; Povidona/química; Compostos de Vinila/química; Modelos Químicos; Estrutura Molecular

Palavras-chave

amorphous solid dispersions; in silico modeling; molecular descriptors; physicochemical meaning; structure−property relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Vinila / Povidona / Composição de Medicamentos / Liberação Controlada de Fármacos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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