The BISAP score, NLR, CRP, or BUN: Which marker best predicts the outcome of acute pancreatitis?
Medicine (Baltimore)
; 100(51): e28121, 2021 Dec 23.
Article
em En
| MEDLINE
| ID: mdl-34941057
ABSTRACT
ABSTRACT Acute pancreatitis is a common disease, and the mortality rate can be high. Thus, a risk assessment should be performed early to optimize treatment. We compared simple prognostic markers with the bedside index for severity in acute pancreatitis (BISAP) scoring system to identify the best predictors of severity and mortality.This retrospective study stratified disease severity based on the revised Atlanta criteria. The accuracies of the markers for predicting severe AP (SAP) were assessed using receiver operating characteristic curves. The sensitivity, specificity, positive predictive value, and negative predictive value were calculated for each marker. Multivariate logistic regression analyses were used to identify independent predictors of SAP and mortality.The area under the curve (AUC) for the BISAP score was classified as fair for predicting SAP. The neutrophil-to-lymphocyte ratio at 48âhours (NLR48âh) and the C-reactive protein level at 48âhours (CRP48âh) had the best AUCs and were independently associated with SAP. When both criteria were met, the AUC was 0.89, sensitivity was 68%, and specificity was 92%. CRP48âh and hematocrit at 48âhours were independently associated with mortality.NLR48âh and CRP48âh were independently associated with SAP but not superior to the BISAP score at admission. Assessing NLR48âh and CRP48H together was most suitable for predicting SAP. The CRP level was a good predictive marker for mortality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pancreatite
/
Biomarcadores
/
Creatinina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Romênia